QUESTION 5 Based on the diagram below, the B cell in the middle is the one that

Question

QUESTION 5 Based on the diagram below, the B cell in the middle is the one that proliferates because RGURE 436 Clonal selection The B cells and Toels in lymph nodes and other lymphatic organs collectively recognee an enormous tumber of antigens tuteach dagran cel recograes only one type of antigen inths bind antigen a 'selected by an antigen to proliferate Antigen molecules to the and into memory oeh and antibodyse ng of Inly one the shown inone on in the shape of he antigen receptors on the i different as thee molecules rather than aspan of amoobe Antigen receptor Antigen variety of Boeis to a clone of identical short ved plasma Clone of plasma cells Oit cloned the free antigen molecules it had the most variety in antigen receptors Its antigen receptor happened to fit the antigen molecules the antigen chose it from among the six B cells shown

Explanation / Answer

The receptor on the B cell is antigen specific and only one specific antigen molecule fits into the receptor. Hence only the B cell in the middle has the receptor for that specific antigen so binds and proliferates.

This is secondary immune response. The B cell in the middle proliferates because of the binding of the antigen to the B cell that already has specific antibody to that antigen. The binding of antigen to B cell already displaying specific antibody to that antigen and interaction with helper T cells stimulates the B cell to divide and differentiate into plasma cells and memory cells.

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