Shown Below is the amino acid sequence of methallothionein. 2-Shown below is the

Question

Shown Below is the amino acid sequence of methallothionein.

2-Shown below is the amino acid sequence of methallothionein. CH3CONH-MetAspProAsnCysSerCysAlaThrAspGlySerCysSerCysAlaGlySerCysLy CysLysGlnCysLysCysThrSerCysLysLysSerCysCysSerCysCysPro ValGlyCysAlaLys SerGinGlyCyslleCys-LysGluAlaSerAspLysCysSerCysCysAla-CO2H a) Do you think this small protein would most probably bind to [Fe", Co". Al 3+ [Cd2+, Hg2+, Pb ? (Please explain) b) Based on your answer for part (a), what is one of the biological function methallothionein in cells?

Explanation / Answer

MT is a protein molecule which have thiol group in the structure so it can bind with zinc Copper and various xenobiotic heavy metals.

MT binds with zinc and regulate the level of zinc in the human body. Zn is important element in the process of transcription.

MT involved in the interaction with the zinc finger motif of other proteins.

involved in various zinc signalling system.

various nerve regulation activities are controlled by this protein.

it is also involved in the regulation of tumor suppressor gene p53.

it is also involved in the control of oxidative stress.

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