A new company has developed a biomaterial (polymer) sheet that can be made porou
ID: 194728 • Letter: A
Question
A new company has developed a biomaterial (polymer) sheet that can be made porous or nonporous, and absorbable (to dissolve in the body) or permanent (non-absorbable). The sheets can be made as thin as 0.2 mm and as thick as 4 mm, and different sheets can be combined to form an implant. In addition, the sheets can be formed into tubes before or after being seeded with cells. You have been hired by the company to assist them in finding applications for the biomaterial.
Applications for the biomaterial in the urinary system (15 points)
One of the consultants to the company has suggested that a sheet of the biomaterial could be used to treat large defects, greater than 6 cm in diameter, in the urinary bladder wall. For this application the company would like to first consider the use of a polymer sheet alone (without cells). Which type of sheet would you think might work best: porous or non-porous, absorbable or non-absorbable? What is the principal problem with the approach that you recommend? Explain your answer.
If a porous, absorbable polymer sheet(s) for the bladder application is to be seeded with cells before implantation, which cell types (name the cell types) would you use and how would you prepare the cell-seeded sheet for implantation? In your answer you should note whether you would use one cell type or more than one cell type and whether your final implant would be made up of one sheet or more than one sheet.
Another consultant to the company has said that a cell-seeded sheet used for the bladder application in “b” could be wrapped around a rod and formed into a tube to be used to replace the ureter and urethra. Do you agree that the sheet prepared for the application in “b” could also be used, in tube form, for these applications? Explain.
Use of the biomaterial as a scaffold to treat blood vessel problems (10 points)
A consultant has advised the CEO of the company to also use the tube in “c” as a replacement for a blood vessel. Do you agree? If you don’t agree, how would you prepare such a cell-seeded implant? Explain your answer.
In preparing a cell-seeded tube for blood vessel regeneration, is there any benefit in employing a bioreactor? Explain. A new company has developed a biomaterial (polymer) sheet that can be made porous or nonporous, and absorbable (to dissolve in the body) or permanent (non-absorbable). The sheets can be made as thin as 0.2 mm and as thick as 4 mm, and different sheets can be combined to form an implant. In addition, the sheets can be formed into tubes before or after being seeded with cells. You have been hired by the company to assist them in finding applications for the biomaterial.
Applications for the biomaterial in the urinary system (15 points)
One of the consultants to the company has suggested that a sheet of the biomaterial could be used to treat large defects, greater than 6 cm in diameter, in the urinary bladder wall. For this application the company would like to first consider the use of a polymer sheet alone (without cells). Which type of sheet would you think might work best: porous or non-porous, absorbable or non-absorbable? What is the principal problem with the approach that you recommend? Explain your answer.
If a porous, absorbable polymer sheet(s) for the bladder application is to be seeded with cells before implantation, which cell types (name the cell types) would you use and how would you prepare the cell-seeded sheet for implantation? In your answer you should note whether you would use one cell type or more than one cell type and whether your final implant would be made up of one sheet or more than one sheet.
Another consultant to the company has said that a cell-seeded sheet used for the bladder application in “b” could be wrapped around a rod and formed into a tube to be used to replace the ureter and urethra. Do you agree that the sheet prepared for the application in “b” could also be used, in tube form, for these applications? Explain.
Use of the biomaterial as a scaffold to treat blood vessel problems (10 points)
A consultant has advised the CEO of the company to also use the tube in “c” as a replacement for a blood vessel. Do you agree? If you don’t agree, how would you prepare such a cell-seeded implant? Explain your answer.
In preparing a cell-seeded tube for blood vessel regeneration, is there any benefit in employing a bioreactor? Explain.
Explanation / Answer
Urinalry tract biomaterials
any biomaterial must undergo rigorous physical and biocompatibility testing prior to its commercialization and use in humans. There are mainly different bulk materials and coatings available in the market for manufacturing of biomaterials, although the ideal material has yet to be discovered.
APPLICATION
For use in the urinary tract, biomaterials may be formed into devices, including urethral catheters and nephrostomy tubes.
It's has an important role as an essential tool in practicing urologist armamentarium.
There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patient's autologous tissues with it's associated morbidity.
Biomaterial used
Natural polymers such as collagen, alginate aand gelatin are mechanically weak. Therefore their medical use is restricted to few sources.
Synthetic polymers such as polycaprolactone, polylactic acid and polyurethane are used. They have various advantages. Their supply is limitless. Furthermore porosity, ultrastructure and surface area to volume, elasticity and degradation can be well handled to match the original tissues. Nevertheless synthetic polymers do lack biological recognition.
concern regarding usage
A cheif concern for using synthetic polymers in urological reconstruction is their to exposure to urine, as the bladder is the main reservoir of urine. Therefore the urine transmit time at it's maximum.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.