5. In the activity \"The Mystery of the Seven Deaths\", the patients all died fr
ID: 202172 • Letter: 5
Question
5. In the activity "The Mystery of the Seven Deaths", the patients all died from cyanide poisoning. Cyanide irreversibly binds to a member of the electron transport chain, which inhibits proton pumping and ATP synthesis. The doctors figured out that the ETC was blocked, since there was too little NAD+ in the patients' cells and too much NADH. How do the aberrant levels of NAD+ and NADH suggest that the ETC was blocked? (Hint the answers from your handout). You m ust use the terms "oxidized" and "recycled" in your answer.Explanation / Answer
The high level of NADH suggests that NADh was not oxidizedin the electron transport chain and converted to generate ATP. Due to non tilization of NADH, there was no recycling of NAD+ in the respiratory cycle. Hence, the mechanism stopped.
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