8. The following table represents characteristics of transgenic and knockout mic

Question

8. The following table represents characteristics of transgenic and knockout mice. (a) Fill in the table, as appropriate b) Below the table, briefly describe how a "knock in" mouse would be developed. In other words, what step (s) would differ for a "knock in" compared to the transgenic and knockout already described. (10 points total) Characteristic Transgenic mice Knockout mice cells receiving DNA zygote (fertilized egg) DNA construct used usually a mutated gene gain of a gene, gene is integrated randomly within the chromosome outcome offspring characteristics all cells carry the transgene, offspring are expected to be heterozygous

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Characteristics cells receiving DNA DNA construct used outcomes offspring characterstic Transgenic mice zygote usually a normal gene from other organisms. Gain of a gene, gene is integrated randomly within the Chromosome. All cells carry the transgene, offspring are expected to be heterozygous Knockout mice uterus of foster mother usually a mutated gene loss of a gene whose function is unknown loss of one gene will have some effect on whole body, different from normal mice.

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