You discovered a natural protein toxin that kills cells by inhibiting the synthe

Question

You discovered a natural protein toxin that kills cells by inhibiting the synthesis of membrane proteins. The toxin contains a stretch of 25 non-polar amino acids and a domain that enables penetration through the plasma membrane. You observed that the great decrease in rough ER but not smooth ER in treated cells. Which of the followings is likely the action mechanism of the toxin?

The toxin makes the plasma membrane permeable to all the ions

The toxin prevents protein translation into ER

The toxin induces the unfolded protein response

The toxin disassembles ribosomes

Explanation / Answer

Correct answer would be:The toxin prevents protein translation into ER

Reason:Rough ER functions in the protein synthesis as well as its folding and since there is a decrease in rough ER , it means the synthesis of protein must have been inhibited by the toxin as toxin might have affected the functioning of rough ER.

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