Chemical uncouplers, such as 2,4-dinitrophenol, have long been of interest as po

Question

Chemical uncouplers, such as 2,4-dinitrophenol, have long been of interest as potential weight-loss drugs
because they promote fat and glucose oxidation without conserving energy in the form of ATP. Uncoupler
compounds
A) inhibit ATP synthesis by binding to ATP synthase proton transport channels.
B) halts all mitochondrial metabolism by hydrolyzing ATP.
C) bind to Fe
2+
in heme, thereby preventing reoxidation of cytochromes in the electron transport chain.
D) dissipate the electrochemical gradient generated by the electron transport chain by shuttling H
+
across
the mitochondrial inner membrane and bypassing ATP synthase.
E) block electron transport by continually reoxidizing coenzyme Q following electron flow through
Complex I or II.

Explanation / Answer

The correct answer is D i.e. It dissipates the electrochemical gradient

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