What would happen to renal acid-base balance if the proximal tubule basolateral

Question

What would happen to renal acid-base balance if the proximal tubule basolateral Na+-K+ ATPase pump was blocked?

a)There would be increased cellular acidosis because of decreased apical Na+-H+ exchanger activity

b)There would be decreased cellular acidosis because of decreased apical Na+-H+ exchanger activity

c)There would be increased cellular acidosis because of increased apical Na+-H+ exchanger activity

d)There would be decreased cellular acidosis because of increased apical Na+-H+ exchanger activity

e)There is no relationship between basolateral Na+-K+ ATPase pumps and apical Na+-H+ exchangers

Explanation / Answer

c) There would be increased cellular acidosis because of increased apical na-h exchanger.

There will be less bicarbonate absorption which is accompanied with H ion exchange , hence H ion concentration will increase leading to acidosis.

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