The example below shows the splicing of a hypothetical, premature mRNA (pre-mRNA

Question

The example below shows the splicing of a hypothetical, premature mRNA (pre-mRNA) transcribed from the gene for yellow fluorescent protein (YFP). Two different YFP mRNAs, isoform A and isoform B, are produced by alternative splicing. What are the possible outcomes of the alternative splicing shown? SELECT ALL POSSIBLE ANSWERS.

UPU BIO K 322 Spring x C fi www.sapl inglearning.com/ibiscms/mod/ibis/view.php?id 3176631 Map Ea Sapling Learning macmillan learning The example below shows the splicing of a hypothetical, premature mRNA (pre-mRNA) transcribed from the gene for yellow fluorescent protein (YFP). Two different YFP mRNAs, isoform A and isoform B, are produced by alternative splicing. What are the possible outcomes of the alternative splicing shown? Unspliced YFP premature m Poly-A tail Spliced YFP mRNA Isoforms Isoform A Cap 5' UTR. Exon 1 Exon 2 Exon 3 3' UTR Poly-A tail 3' UTR Poly-A tail Isoform B 5' UTR Exon 3 The protein translated from isoform B is stable but lacks a functional domain. Exon 2 will be added to isoform B later to correct the mistake in splicing. l The protein translated from isoform-A mRNA possesses an additional functional domain. The alternative splicing of YFP pre-mRNA prevents 5' capping. soform-A mRNA is degraded faster than isoform-B mRNA is. Search right here 0:27 P

Explanation / Answer

The possible outcomes would be:

1. The protein translated from isoform B is stable, but it lacks a functional domain

2. The protein translated from isoform A mRNA possesses an additional functional domain (Exon 2).

3. Isoform-A mRNA is degraded faster than isoform-B mRNA

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