Several members of a family exhibit the symptoms of myotonic dystrophy, a condit
ID: 253260 • Letter: S
Question
Several members of a family exhibit the symptoms of myotonic dystrophy, a condition typified by wasting away of muscles and a variety of other problems. The pedigree of the family is shown to the right. The gene responsible for the disease is on chromosome 19 and is preceded by a long untranslated stretch of repeated GCT nucleotides that are 5’ to the gene. DNA is isolated from the living members of the pedigree shown and the length of the 5' region is determined. The numbers of repeats for each individual are shown on the pedigree.
a. Why are two numbers shown for each individual?
Famdly with Myotanic Dystrophy 2 3 69 5/13 2 /M B 6/76 14/16 13/aa 2 3 6 14/14113/11213/ 5/16g15/24 16/20 14/100Explanation / Answer
a) The two number for each individual show the number of repeat units that is present in the genome of an organism in comparison to the other repeating units.
b) Myotopic dystrophy is an autosomal dominant trait which is capable of causing the disease even if the single dominant allele of the gene is present in the genome of an organism. This disease occurs due to increase number of trinuclotide repeats in the genome. Myotopic dystrophy could be a congenital diorder and can be passed on from affected mother's to it's new born babies.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.