Case 3: The Parched Professor Your last call is to the aid of Professor Purple.

Question

Case 3: The Parched Professor Your last call is to the aid of Professor Purple. Three witnesses are present from whom t Witness statementss are present from whom to take statements 1 M. Ohe: "Iswear that I saw him drink a full glass of water every half an hour today. He kept saying how thirsty was! 1 Mrs. Blanc "He must be going to the well, you know, the little boys' room, two or three times every hour 1Ms. Feather"He's een saying lately that his mouth is dry and that he feels weak. Personally, I think he's just not following a healthy diet. He should be drinking some of my herbal teas! Based upon the witnesses' statements, what are your initial thoughts? Does one hormone come to mind that could produce these effects? Explain. You interview Professor Purple and collect blood and urine specimens to be sent off to the lab for analysis. The lab reports that the urine osmolality is 150 mOsm/kg, which means the urine is overly dilute (too much water in the urine The blood osmolality is 300 mOsm/kg, meaning the blood is overly concentrated (too little water in the blood). The lab also reports that his blood glucose is completely normal. What is the significance of these clues? 16 Based upon the witness statements and the laboratory analysis, what is your final diagnosis? (Hint: Think of the hormone hat is supposed to trigger water retention from the kidneys. Is there a disease where this hormone is deficient?) Explain Prof. Purple's symptoms Endocrine System UNIT 16437

Explanation / Answer

Based on the witnesses, Vasopressin or Anti Diuretic Hormone (ADH) comes to my mind. Excess fluid loss through urination, frequent feeling of thirst are symptoms of lower secretion of ADH.

THe significance of these clues further confirm my initial diagnosis of ADH defect. Since the blood glucose levela are normal, it rules out Diabetes mellitus. People with diabetes also have excess thirst and excess urination. Due to inappropriate ADH secretion, there would be hyponatremia (low sodium in urine) and hypo osmolality and hyper osmolality of blood. It is evident from the laboratory tests.

So, my final diagnosis is Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

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