Which of the following mutational changes would be predicted to harm an organism

Question

Which of the following mutational changes would be predicted to harm an organism? Explain your answers.
A. Insertion of a single nucleotide near the end of the coding sequence.
B. Removal of a single nucleotide near the beginning of the coding sequence.
C. Deletion of three consecutive nucleotides in the middle of the coding sequence.
D. Deletion of four consecutive nucleotides in the middle of the coding sequence.
E. Substitution of one nucleotide for another in the middle of the coding sequence.

Explanation / Answer

A. Insertion of a single nucleotide near the end of the coding sequence.

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