Researchers investigated the ability of individuals to digest or metabolize diff

Question

Researchers investigated the ability of individuals to digest or metabolize different amounts of the drug, flutamide, which is a drug used to treat prostate cancer. The diagram below represents ABA the catabolic reaction that occurs to digest flutamide in the cell BA Flutamide hydroxylase gs in Pn It. Consider the results from their study for Question 42-44 0.40 cells E 0.3S Filled circles: individual A 0.30 S E 0.25 0.20 0.15 Open squares: Individual B Filled triangles: Individual C 0.10 0 005 0 100 200 300 400 500 600 700 800 Flutamide (rM) 42. What is the role of flutamide hydroxylase in this reaction? on A) It is the substrate B) It is the product C) It is a cofactor D) It is an enzyme 0.1%) 43. What have the researchers manipulated in the study presented the graph? A) The amount of enzyme available B) The amount of substrate available C) The time for the reaction to occur D) The amount of inhibitor available 44. Why does individual C exhibit such low reaction rates? Choose the best answer. Individual C has a much lower body temperature Flutamide concentrations are lower in Individual C Individual C produces fewer functional flutamide hydroxylase molecules Flutamide hydroxylase is more likely to bind to flutamide in individual C A) B) C) D)

Explanation / Answer

42. Any biological compound's name ending with '-ase' means that it is an enzyme. So, flutamide hydroxylase is an enzyme. Different enzyme works in a different chemical manner. Hydroxylase function by inserting a hydroxyl group into its substrate.

43. Here, flutamide is the substrate. Enzyme+Substrate = Product + Enzyme. Enzyme is actually a biological catalyst which is why they are regenerated after reacting with the substrate and producing the product. Therefore, the researchers have manipulated with the amount of the substrate available.

44. A) Enzyme always work with full specificity at a particular temperature. If the temperature is much lower than normal then enzyme will not work.

B) Flutamide concentration can not be lower as is evident from the graph

D) If flutamide hydroxylase is more likely to bind to flutamide in individual C, then the reaction can occur optimally.

Therefore, the lower rate of the reaction can only happen if the individual C has fewer functional flutamide hydroxylase molecules. So, the correct answer is C.

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