Holliday intermediates in homologous genetic recombination differ from those in

Question

Holliday intermediates in homologous genetic recombination differ from those in site-specific recombination based on whether branch migration typically occurs. Choose the statements below that describe this difference in mobility throughout the genome. Branch migration only occurs when replication stalls to force replication enzymes through the stopping point. Holliday intermediates can form almost anywhere between two paired, homologous chromosomes Branch migration in site-specific recombination is generally restricted by the presence of heterologous sequences flanking the recombination site. DNA ligase fails to seal the nicks in mobile Holliday intermediates. Mobile Holliday intermediates form only on prokaryotic chromosomes, while immobile Holliday intermediates form on eukaryotic chromosomes

Explanation / Answer

In site specific recombination branch migration occur between the flanking recombination sites. Like Cre-lox site specific recombination recombunation occur between loxP sites but in holiday junction recombination occur randomly. Option C is correct

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