QUESTION 3 Shown below are four graphs of velocity with respect for substrate co

Question

QUESTION 3 Shown below are four graphs of velocity with respect for substrate concentration and their associated double reciprocal plots. Match the following statements with the appropriate curve or line 100 A. C. E. None of these 1/[S] Graph I Graph lI A. C. +The line corresponding to curve D E. ? The curve corresponding to line 4 E. The curve corresponding to an enzyme catalyzed reaction in the Line 1 B. Line 2 C.Line 3 D. Line 4 E. Curve A F. Curve B G. Curve C absence of inhibitor G. + The curve that corresponds to negative feedback regulation The curve that represents an inhibitor that effectively removes enzyme from the active population The curve that represents inhibition by a transition state analog. H Curve D More than one of these None of these The line that represents an inhibitor that binds immediately adjacent to the active site of the enzyme The curve corresponding to a competitive inhibitor

Explanation / Answer

The graphical data shown in the image shows a normal distribution curve as well as a Lineweaver-Burk plot for enzyme catalysed reactions under variuos conditions of competetive, non-competetive and mixed inhibitors. The correct matches can be found as below:

Answer 1: Choice A (Shows un-competetive inhibition)

Answer 2: Choice G (Shows un-inhibited enzyme catalysis)

Answer 3: Choice D (Line 3 and curve C correspond to un-inhibitored enzyme catalysis)

Answer 4: Choice H (As a negative feedback regulator comes into action of enzyme catalysis, the rate of reaction falls drastically)

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