10. Assume that the amino acid sequence of the DNA-binding domain of Jun is RNRI
ID: 261410 • Letter: 1
Question
10. Assume that the amino acid sequence of the DNA-binding domain of Jun is RNRIAASKCR. Which amino acids in this domain might participate in ionic interactions with the sugar-PHOSPHATE backbone of the DNA?
11. Assume that first division non-disjunction occurs for chromosome 1 in a human primary spermatocyte. How many resulting spermatozoa would be capable of producing a viable offspring following fertilization of a healthy oocyte?
12. Assume that second division non-disjunction occurs for chromosome 1 in a human primary spermatocyte. How many resulting spermatozoa would be capable of producing a viable offspring following fertilization of a healthy oocyte?
Explanation / Answer
10. RNRIAASKCR = Arg-Asn-Arg-Ile-Ala-Ala-Ser-Lys-Cys-Arg
Arginine and lysine are positively charged amino acids and can interact with negatively charged sugar-phosphate backbone of DNA.
11. All the four daughter cells will have altered number of chromosomes. Thus all offsprings will be affected.
12. Only two out of four daughter cells will have altered number of chromosomes. Thus 50% offsprings will be affected.
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