4A. (3pts) One of the following statements is generally accurate, and the other

Question

4A. (3pts) One of the following statements is generally accurate, and the other one is not. an "" next to the inaccurate statement and provide a counter-example. put an "A" next to the accurate statement and provide a supporting example. Please put GEF's activate signaling proteins, while GAP's inactivate them. Supporting or counter-example: Kinases activate signaling proteins, while phosphatases inactivate them. Supporting or counter-example: B. (3pts) Do you AGREE or DISAGREE with the following? Please provide your reasoning. The changes that kinases and phosphatases make to proteins are both energetically favorable. Circle: Reasoning: AGREE or DISAGREE

Explanation / Answer

4A:-

Answer:-GEFs activate signalling proteins, whereas GAPs inactivate them -A ( Acccurate)

Explanation:- Guanine nucleotide exchange factors (GEFs) are proteins that bring exchage of GDP and GTP on G-protein to make them active (GTP-G protein form) whereas GAP ( GTPase activating protein) inactiivate protein by bringing hydrolysis of GTP.

Answer:- Kinases activate signalling proteins,while phosphatases inactivate them- A( accurate)

Explanation:- Kinases bring ATP near the protein to be modified and transfer phosphate group from ATP on amino acid of protein ( serine, threonine,tyrosine) and activate them , whereas phosphatases bring water and break phosphodiester bond bring de phosphorylation of amino acid thus inactivate them.

B:- Agree

Explanation:- Both these processes are energetically favourable as there is negative del G ( gibbs free enrgy)

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