A mutation occurs in a gene encoding for tRNAT. The mutation occurs in the regio

Question

A mutation occurs in a gene encoding for tRNAT. The mutation occurs in the region encoding the anticodon portion of the tRNA. A fragment of the template strand of the WT and mut genes are shown below. The mutated base is underlined WT: 5' TAC3' Mut: 5' TAA 3 15) The mutant tRNA is still charged with tyrosine by aminoacyl tRNA synthetase and all that is affected is the changed nt in the anticodon. What will be the consequences of this mutation on protein synthesis? How do you think this will overall affect the organism with the mutation?

Explanation / Answer

tRNA function as an interpreter that reads sequence on mRNA and fits correct amino acid during translation.tRNA has an anticodon which is complementary to the mRNA codons.suppose if mRNA has codon UAC the anticodon will have codon AUG.

The tRNA binds to the codon complementary to the mRNA and then attaches the amino acid which is attached to tRNA.amino acid which is attaches to tRNA is dependent on the codon on mRNA.suppose GGG is codon on mRNA then glycine will be attached to tRNA with anticodon CCC.So in Bove example if the tyrosine remains still attached even after mutatation but anticodon is changed then the tRNA cannot bind to the specified mRNA and thus cannot attach tyrosine in protein sequence during translation.

The organism will be having defective protein who might be disfunctioning.

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