A mutation results in a cell that no longer produces a normalprotien Kinase for

Question

A mutation results in a cell that no longer produces a normalprotien Kinase for the M phase checkpoint. Which of the followingwould likely be the immediate result of this mutation: A) The cell would undergo normal mitosis but fail to enter thenext G1 phase. B) The cell would never leave metaphase. C) The cell would never enter metaphase. D) The cell would never enter prophase. E) The cell would prematurely enter anaphase A mutation results in a cell that no longer produces a normalprotien Kinase for the M phase checkpoint. Which of the followingwould likely be the immediate result of this mutation: A) The cell would undergo normal mitosis but fail to enter thenext G1 phase. B) The cell would never leave metaphase. C) The cell would never enter metaphase. D) The cell would never enter prophase. E) The cell would prematurely enter anaphase

Explanation / Answer

Checkpoints are quality-control systems. When defect arises,checkpoints will stop cell cycle progression until defects arecorrected for the cell to progress to the next stage. In M phase, there are 3 stages which are regulated (1) Entry into M-phase (2) Metaphase to anaphase (3) Exit from M-phase In this transition, the spindle assembly checkpoint safeguards theintegrity of genome. If the sister chromatids are not properlysegregated, the checkpoint will induce metaphase arrest whichprovide more time for all kinetochores to be properly attached tothe spindle microtubules. So, when there is mutation in the proteinkinase for the M phase checkpoint, then the spindle assemblycheckpoint will not be functioning. So, from the choices of five,it is very confirmed that the answer is (E) The cell wouldprematurely enter anaphase Hope this helps!

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