Question 24 (6 points) 6 points) Tay-Sachs disease is a debilitating disorder th

Question

Question 24 (6 points) 6 points) Tay-Sachs disease is a debilitating disorder that is characterized by neural degeneration early in infancy and leads to death within 2-4 years of birth. Symptoms begin with a loss of voluntary movement, and will be followed by swallowing difficulties, decerebrate posturing, increasing seizures and then a pronounced vegetative state. Amongst the population in North America, the incidence of the disorder is 1 in 360,000. a) (2 points) Please calculate both p and q (the frequencies of the wild-type (dominant) and the disease causing (recessive) allele. b) (2 points) Please calculate the frequency of homozygotes for the dominant, wild-type allele in the North American population. c) (2 points) Please calculate the frequency of heterozygotes in the the North American Population. FS 3 4 5 7 9

Explanation / Answer

Answer:

Based on the given information, incidence of Tay-Sachs disorder in North American population = 1/360000

Therefore the answer to given questions are:

a) p = 0.9983 and q = 0.00167

b) Frequency of homozygotes for dominant (TT) = p2  = 0.9967

c) Frequency of heterozygote (Tt) = 2*p*q = 0.0033

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