What are the implications of a study with a conclusion of? At the conclusion of

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What are the implications of a study with a conclusion of?

At the conclusion of the study, the IBDNF (inflammatory bowel disease nutrition formula) group had a 35%-65% greater decrease in corticosteriod dosage compared with the controls with similar refuctions in disease acitivty, thus supporting its use as an adjuvant therapy in patients with ulcerative colitis. The results show that the addition of a dietary supplement enriched with fish oil, probiotics and antioxidants in CD (Chron's disease) results in increased fat-free and fat mass deposition, impoved vitamin D status and impovement of quality of life and lowered disease activity

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Our results show that the addition of a dietary supplement enriched with fish oil, prebiotics, and antioxidants in CD results in increased fat-free and fat mass deposition, improved vitamin D status, and an improvement in quality of life and lower disease activity.

Several studies have investigated the effects of exclusive EN for the induction and maintenance of remission in CD. These studies have shown that EN is inferior to corticosteroids for adults with CD.34More promising results have been shown in children with CD treated with EN.35 One of the major problems with EN as the sole source of nutrition in adults is the high rate of noncompliance, which is partly due to the fatigue associated with a monotonous diet. There have been a small number of trials using EN as an adjuvant to a normal adult diet. On the other hand, in children, supplementation of a normal diet with nocturnal enteral feedings has resulted in prolongation of remission.36 This study was unique because the nutrition intervention was offered as a supplement to the normal adult diet. We did not place any restriction on oral intake other than the supplement and encouraged patients to eat as they normally would.

Patients with CD may avoid fiber due to physician-prescribed trials of low-residue, low-fiber diets during periods of intestinal narrowing. However, the role of viscous fiber for its prebiotic and short-chain fatty acid effects has shown significant promise, and the role of a chronic low-residue, low-fiber diet is not established.41 Although most of the changes in intake are attributed to ingredients of the supplement, a randomized controlled trial comparing IBDNF with an isocaloric, isonitrogenous supplement would provide additional information on the benefit of the fish oil, prebiotics, and antioxidants over a generic nutrition supplement.

The primary goal of this study was not to assess disease activity; however, we recognize this is an important part of any intervention and included information on CDAI, IBDQ, and CRP. Patients were enrolled in our study if they had clinical signs of active disease; most but not all patients had a CDAI >150 at enrollment. We believe that the statistically significant decrease in CDAI of 47.8 points was clinically significant because this put most of the patients at a CDAI below 150. The decrease in CDAI was accompanied by a statistically significant increase in the IBDQ. Previous studies have reported correlations between disease activity and IBD-specific quality of life with Pearson coefficients of 0.6–0.7.

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