Chapter 32 (Nucleotide Metabolism) Chapter Objectives 1. What are the two differ

Question

Chapter 32 (Nucleotide Metabolism) Chapter Objectives 1. What are the two different methods of synthesizing nucleotides? 2. Compare and contrast purine and pyrmidine metabolism. 3. What are the common precursors for nucleotide metabolism? 4. How are deoxyribonucleotides made? 5. How is nucleotide biosynthesis regulated? How is the enzyme ATCase regulated? 6. How are cancer therapies tailored to nucleotide synthesis -explain using the example of fluorouracil and methotrexate. Important Terms and Comparisons Nucleotide vs nucleoside PRPP Carbamoyl phosphate synthetase Purine and pyrimidines Salvage and de novo pathways Ribonucleotide reductase Thymidylate synthetase Dihydrofolate reductase

Explanation / Answer

1. what are the two different methods of synthesising nucleotides?

The two different methods of synthesis of nucleotides are pyrimidine synthesis and purine synthesis.

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