Identify a research or evidence-based article that focuses comprehensively on a

Question

Identify a research or evidence-based article that focuses comprehensively on a specific intervention or new diagnostic tool for the treatment of diabetes in adults or children.

In a paper of 750-1,000 words, summarize the main idea of the research findings for a specific patient population. Research must include clinical findings that are current, thorough, and relevant to diabetes and the nursing practice.

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Explanation / Answer

Incretin Replacement Therapy: A New Treatment Tool for Type 2 Diabetes

L. Blonde, MD, FACP, FACE; Om Ganda, MD; Planning Committee: Richard S. Beaser, MD; Enrique Caballero, MD; Ramachandiran Cooppan, MD; Om Ganda, MD; Sharon Garbus; James E. Neighbours, MEdL.(sunday 22 july 2018). Incretin Replacement Therapy: A New Treatment Tool for Type 2 Diabetes. Incretin Replacement Therapy: A New Treatment Tool for Type 2 Diabetes, 1-2. Retrieved July 23, 2018, from https://www.medscape.org/viewarticle/549215.

Evidence based article by health care professionals

Institution (CME)

The Joslin Diabetes Center, Boston, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians

The article was developed by primary care physicians and health care professionals who are engaged in treatment of patients with diabetes and diseases related to it.The article explains the the action of incretins and the pathophysiology of diabetes from the view of incretin function and look to the treatment plan for therapies that can replace natural incretin function.

This article helps in identifying the multiple pathophysiologic abnormalities that contribute to the signs and symptoms of type 2 diabetes and the treatments. It also initiates an appropriate spectrum of type 2 diabetes treatments in response to all clinically identified abnormalities in the interrelationships among glucose metabolism, insulin action, and pancreatic endocrine function. It manage treatments that impact insulin secretory function through incretin replacement therapy .Achieve optimized glucose control more effectively utilizing comprehensive diabetes treatments involving pancreatic functions that extend beyond direct glucose impact to the neuroendocrine and/or GI systems..

Th article explains about important incretins in body. They are gastric inhibitory polypeptide(GIP) and glucagon-like peptide-1(GLP-1). Type 2 diabetes patients have a resistance to GIP, making it a less acting against diabetes. GLP-1 is a 30-amino acid peptide secreted in response to the oral ingestion of nutrients by L cells, primarily in the ileum and colon. There are GLP-1 receptors in islet cells and in the central nervous system, among other places. GLP-1 is metabolized by the enzyme dipeptidyl peptidase-IV (DPP-IV), and the secretion and levels of GLP-1 are decreased in people with type 2 diabetes.GLP-1 stimulates insulin synthesis and helps to consume less food.In a small study of patients with type 2 diabetes, infusion of GLP-1 resulted in an increase in insulin, a decrease in glucagon, and a decrease in glucose which proves that incretin therapy is useful intervention in treatment of type 2 diabetes patients.

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