• Title of your article Association of Selective Serotonin Reuptake Inhibitor Ex

Question

• Title of your article Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring

• Why you did this study

• Why this area of research is important

• Gaps in the literature (What we don’t know and what this study will add to nursing science)

• Type of research (Quantitative or Qualitative)

• Overview of the research methods, including number of participants, and general demographics

• Study results • Implications for nurses

Explanation / Answer

I did this study because it helpful to examine wether ssri exposure during pregnancy with speech, scholastic, and motor disorders in offspring upto early adolesence. Importance of this area of research is that this speech/language, scholastic, and motor disorder are common in children. And it is unknown whether exposure to selective serotonin reuptake inhibitors during pregnancy influences susceptibility to these disorders. This study will add implications for understanding association between ssris and child development. This quantitative type of research. Overview- This prospective birth cohort-study examined national population based register data in Finland from 1996-2010. The sampling frame includes 845 345 pregnant woman and their singleton offspring with data on maternal use of antidepressants and depression related psychiatric disorder during pregnancy. Study Results of the 56 340 infants included in the final cohort, 28684(50.9%) were male and 48782(86.6%) were 9 years or younger. The mean age of children at diagnosis were 4.43(1.67),3.55(2.67) and 7.73(2.38) for speech, scholastic and motor disorder respectively. Offspring of mothers who purchased ssris at least twice during pregnancy had a significant 37% increased risk of speech disorders compared with offspring in the uneducated group. The cumulative hazard of speech disorders was 0.0087 in SSRI exposed group Vs 0.0061 in the unmedicated group (hazard ratio, 1.37, 95% CI, 1.11-1.70, p= .004). There was a significant increased risk of these disorders in offspring in the SSRI exposed and unmedicated group. For scholastic and motor disorders, there were no difference between offspring in the SSRI exposed group and in the unmedicated group. Implications for nursee is that for understanding association between SSRIs and child development.

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