28) Intreating Crohn\'s disease, the recommended dose of the monoclonal antibody

Question

28) Intreating Crohn's disease, the recommended dose of the monoclonal antibody adalimumab (HUMIRA) is 160mg as the first dose, a second of 80mg 2 weeks later, then a third dose of 40mg 2 weeks after the second dose, and followed later, then a third dose of 40 mg 2 weeks after the second dose, and followed by a maintenance dose of 40 mg every 2 weeks. How many prefilled syringes, each containing adalimumab, 40/0.8mL, would be required for the initial 2 months of treatment?

30) The biotechnology drug pegintrferon alpha-2b is administered at a starting drug ia available in single-use 0.74-mL injections contaianing 40 mcg/0.1 mL, 60 mcg/0.1 mL, or 120mcg/0.1 mL. Which product size would be most efficacious for administration to a 156-ib patient?

32) A 16-week regimen for a brand of a nicotine patch calls for a patient to wear a 21-mg patch each day for the first 6 weeks, followed by a 14-mg patch each day treatment regimen. In all, how many milligrams of nicotine are administered?

33) A transdermal patch contains 5mg of fentanyl and has a drug-releaserate of 50mcg/hpur. The patch is worn for 72hours. Calculate a) the milligrams of fentanyl delivered daily, b) the milligram of fentanyl remaining in the patch when it is removed.

37) SYMBICORT 80/4.5 is an oral inhalation product containing 80 mcg of budesonide and 4.5 mcg of formoterol fumarate per inhalation. The dose is stated as "two inhalations twice daily". How muich of each drug would be administered daily? a) 8g diclofenac sodium per day for 8 days. b) 8g diclofenac sodium per day for 12.5 days. c) 80 mg diclofenac sodium per day for 8days. d) 0.08g diclofenac sodium per day for 12.5 days. Expert Answer

Explanation / Answer

28) Total 0f 9 syringes

30) 60 mcg/0.1 mL

32) 1st 6 six weeks i.e 42 days; 42x21mg=882mg

Then 10 weeks i.e 70 days; 70x14mg=980mg

Total=882+980= 1862mg

33) a) the milligrams of fentanyl delivered daily = 50 x24= 1200 i.e 1.2 mg

b) the milligram of fentanyl remaining in the patch when it is removed.

For 72 hours 3.6 mg of fentanyl used,so remaining 1.4 mg

34)   c) 80 mg diclofenac sodium per day for 8days

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