As an epidemiologist you are going to investigate the effect of a drug suspected
ID: 3152020 • Letter: A
Question
As an epidemiologist you are going to investigate the effect of a drug suspected of causing malformations in newborn infants when the drug in question is taken by pregnant women during the course of their pregnancies. As your sample you will use the next 200 single births occurring in a given hospital. For each birth a medication history will be taken from the new mother and from her doctor; in addition, you will review medical records to verify use of the drug. [N.B.: These mothers are considered to have been followed prospectively during the entire course of their pregnancies, because a complete and accurate record of drug use was maintained during pregnancy. the resultant data are forty mothers have taken the suspected drug during their pregnancies. of these mothers, 35 have delivered malformed infants. in addition 10 other infants are born with malfunctions. what is the relative risk between exposure to the drug and malformations?
Explanation / Answer
As an epidemiologist you are going to investigate the effect of a drug suspected of causing malformations in newborn infants when the drug in question is taken by pregnant women during the course of their pregnancies. As your sample you will use the next 200 single births occurring in a given hospital. For each birth a medication history will be taken from the new mother and from her doctor; in addition, you will review medical records to verify use of the drug. [N.B.: These mothers are considered to have been followed prospectively during the entire course of their pregnancies, because a complete and accurate record of drug use was maintained during pregnancy. the resultant data are forty mothers have taken the suspected drug during their pregnancies. of these mothers, 35 have delivered malformed infants. in addition 10 other infants are born with malfunctions. what is the relative risk between exposure to the drug and malformations?
Drug
No drug
Malform
35
10
45
No Malform
5
150
155
40
160
200
risk in Drug group =35/40
risk in no Drug group =10/160
Relative risk = (35/40) / (10/160) =14
Drug
No drug
Malform
35
10
45
No Malform
5
150
155
40
160
200
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