What would happen to the commensal relationship between the gut and gut microbio

Question

What would happen to the commensal relationship between the gut and gut microbiome if there was a defect in mucosal immunity, and IgA levels dropped?

What would happen to the commensal relationship between the gut and gut microbiome if there was a defect in mucosal immunity, and IgA levels dropped?

Microbes would penetrate the gut and induce immunological tolerance Nothing, because microbes would overgrow in the gut and die as IgA levels dropped Nothing, because other arms of the immune response would compensate Microbes would penetrate the gut and trigger chronic inflammatory responses

Explanation / Answer

If IgA levels drop in gut the individual becomes immune compromised and microbes would penetrate gut and trigger chronic inflammatory responses.

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