3. The relationship between serum cholesterol and coronary heart disease seems t

Question

3. The relationship between serum cholesterol and coronary heart disease seems to follow a "dose-response" pattern. A serum cholesterol concentration test based on blood obtained by finger-stick in non-fasting individuals was considered for use in a large cohort study of risk factors for coronary heart disease. A pilot study was also conducted comparing results from this test with those obtained by assaying serum cholesterol in a nationally recognized standard laboratory. The results are shown in the table below. In this table, "positive" values refer to a serum cholesterol concentration of 2 200 mg/dL. (5 marks) Standard Laboratory Values Finger Stick Test Values Positive Positive Negative 19 18 Negative Find the sensitivity [1 mark], specificity [1 markj, number of false positives ?0.5 mark. false negatives [0.5 mark], positive predictive value [1 mark], and negative predictive value [1 mark] the finger stick test for diagnosing high serum cholesterol.

Explanation / Answer

SENSITIVITY: 18/19=0.947368421

SPECIFITY: 11/30=0.37

NO OF FALSE POSITIVE; 19

NO OF FALSE NEGATIVE : 1

POSITIVE PREDICTIVE VALUE: 18/37=0.486486486

NEGATIVE PREDICTIVE VALUE; 11/12=0.917

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