Based on your understanding of skeletal muscle contraction, what do you predict

Question

Based on your understanding of skeletal muscle contraction, what do you predict happens in Malignant Hyperthermia when halothane is administered to susceptible individuals? Why don’t individuals with MH have any effect of anesthetics on cardiac muscle contraction even though they also possess ryanodine receptors? Increase calcium release from SR Decrease calcium release from SR Increase calcium uptake into the SR All of the above Which steps, out of the choices, in muscle contraction require ATP? Cross bridge detachment Calcium sequestration Na-K pump All steps require ATP

Explanation / Answer

Malignant hyperthermia, it is an autosomal dominant disorder and there are about 6 genetic loci of interest. When the affected person is exposed to general inhalational anaesthetics, hyper-metabolism in muscles occurs. This disease is life threatening if left untreated. Early diagnosis is possible by genetic testing, and caffeine halothane contracture test (CHCT) is generally used. Administration of halothane to these individuals increase the cytoplasmic calcium levels.

The anesthetic does not affect the cardiac muscle because mutation affects only the RYR1 receptors present in the skeletal muscles, they are absent in cardiac muscles.

Related Questions

Navigate

• Browse (All)
• Browse B
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.