Glumerular Filtration Rate Questions Please answer througly Glomerular Filtratio

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Glumerular Filtration Rate Questions Please answer througly

Glomerular Filtration Rate Describe the effect that an increasing blood pressure (i.e. MAP) would have on GFR if the kidneys could NOT compensate for this change? Describe the effect increasing blood pressure would have on the volume of urine produced if the kidneys could NOT compensate for this change? In the human body, if MAP is between 80 and 180mmHg, would GFR be expected to change as MAP changes? Explain your answer. What would happen to GFR if MAP rises above 180mmHg? Explain your answer, including the exact stimulus and process for producing this change. What would happen to GFR if MAP falls below 80mmHg? Explain your answer, including the exact stimulus and process for producing this change.

Explanation / Answer

If the mean arterial pressure (MAP) increases, renal autoregulation causes the afferent arteriole to constrict, preventing the pressure increase from being transmitted to the glomerular capillaries, and keeping the GFR from increasing.

Where as, decreased MAP is detected by arterial baroreceptors, which leads to sympathetic nervous system activation, afferent arteriole constriction, and decreased GFR.

Increased blood pressure causes increased glomerular filtration rate and urine output.

To provide adequate renal perfusion, MAP must be at least 65 mm Hg. When BP or blood flow to the kidneys decreases and MAP falls below 65 mm Hg, both urine output and the glomerular filtration rate (GFR) decline.

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