Exercise 16-4 Endocrine \"Mystery Cases\" n this exercise you will be playing th

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Exercise 16-4 Endocrine "Mystery Cases" n this exercise you will be playing the role of "endocrine detective" to solve endocrine discase mysteries. In each case you will have a victim who has saddenly fallen ill with a mystcrious malady. You will be presented a set of "witnesses, each of whom will give you a clue as to the nature of the illness. Other clues will come from samples you send off to the lab for analysis. You will solve the mystery by peoviding the victim a diagnosis. You may wish to use your textbook for assistance When you have completed the cases, answer Check Your Understanding question 7 (p. 444), Case 1: The Cold Colonel You are called upon to visit the ailing Col. Lemon. Before you see him, you speak with three witnesses who were with him when be fell ill Witness statements Ms. Magenta: "Col. Lemon has been hot-blooded for as long as Il've known him. But I noticed that he couldn't seem to keep warm. He kept complaining about being cold. Mr. Olive "Just berween you and me, I've noticed that the old chap has put on quite a bit of weight lately the energy to do much of anything ! Professor Purple: "The colonel and I used to go on major expeditions together. Now he just doesn't seem to have t are your initial thoughes about the witnesses' statements? Does one hormone come to mind that may be the cause? Explain. 16 the colonel and collect some blood to send off to the lab. The analysis comes back as follows (triodothyronine): 0.03 ng/dl (normal: 0.2-0.5 ng/dl) T4 (thyroxine): 1.1 /dl (normal: 4-7 Pg/dl) TSH (thyroid-stimulating hormone): 86 mUN (normal: 0.3-4.0 mLM) Analyze the results. Why do you think the T3 and T4 are low and the TSH is elevated? Based upon the witness statements and the laboratory analysis, what is your final diagnosis? Explain Col. Lemon's symptoms. Endocrine System UNIT 16 435

Explanation / Answer

1. It looks from the evidence of observants that the patient is suffering from a disease called hypothyroidism and the hormone responsible for this disease is thyroxine. The is harmony is mainly secreted by thyroid gland which is responsible for various biochemical activities in human body

2. The harmones T3 and T4 are secreted by thyroid gland it's secretion is balanced by a hormone TSH secreted by pituary gland .as laboratory report show T4 and T3 level is below the normal range and TSH is too high than the normal range .the reason for imbalance in harmonies is due to feed back mechanism when T4 and T3 level decreases in blood it sends signals to thyroid gland which drops more TSH hormone in blood and vice versa.that is why as the level of T4 and T3 level is low the level of TSH is high

3. The laboratory records and witness observation clearly suggest that it the hypothyroidism the common symptoms for this disease which col lemons faced are fatigue , weakness , intolerance to cold, muscle ach and cramps , weight gain, poor appetite, constipiation and goitre.

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