The following refer to Figure 5.1, page 131 in Silverthorn Pl ysiology text. Int

Question

The following refer to Figure 5.1, page 131 in Silverthorn Pl ysiology text. Intracellular Fluid (ICF)-28 liters (L) 2/3 of total body water Extracellular Fl uid (ECF) 14L-1/3 of total body water Plasma: 25% of ECF Interstitial Fluid-75% of ECF Questions: 1. Using the ECF volume for the Standard 70 kg man in 5.1b, calculate the volumes of the a. Plasma- b. Interstitial Fluid 2. What is the total body water volume of this person? 3. Calculate the percentage of total body water in the plasma and interstitial fluid. a. Plasma- b. Interstitial Fluid A woman weighs 121 pounds. Assuming her body water weight is 50% of her total b calculate the ECF, ICF and Plasma volumes. Use the standard proportions for the flu compartments. (2.2 pounds 1 kilogram. 1 kg water 1L). Show your calculations below. 4. a. ICFL Plasma L s. How does the ion composition of the plasma differ from that of the IF? 6. What ions are concentrated in the ECF? In the ICF? a. ECF: b. ICF:

Explanation / Answer

1]

Plasma

Plasma is 25% of ECF that is;

25/100 × 14 = 3.5 L.

Interstitial fluids

It is 75% of ECF

75/100 × 14 = 10.5 L

2] total body water = extracellular fluid + intracellular fluid

= 14 L + 28 L = 42 L

TBW = 42 L

3] a) plasma = 8 %

b) interstitial fluid = 25 %

4] 121 pounds is 55 kgs.

Body water weight = 50 % of total body weight

= 50/100 × 55 kgs = 27.5 kgs.

Total body water(TBW) is 27.5 kgs = 27.5 L

ECF = 1/3 of the TBW = 27.5/3 = 9.18 L

ICF = 2/3 of TBW = 2/3 × 27.5 = 2 × 9.18 = 18.36 L

Plasma = 25% of ECF = 25/100 × 9.18 L = 2.295 L

5] ionic composition of plasma and IF ( conc in mEq/ L of water)

Plasma ; total ions = 326 ( cations = 163 and anions 163)

Cations ;Na+ = 153 ,K+5.4, Mg+2 = 1.9 ,others = 2.7

Anions; Cl- =111, HCO3- =26.2, Phosphate = 1,proteins = 17.2,others =7.6

Interstitial fluid

Total ions = 308 ( cations = 154 and anions = 154)

Cations; Na+ = 145, K+ = 5, Mg+2 = 2,others=2

Anions; Cl- 110,HCO3- = 2,phosphate = 2,proteins= 15

6)] ECF; Na+,K+, Cl-,HCO3-

ICF; K+,Mg+2, phosphates and proteins

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