HELP ASAP!! QUESTION 4 A neuron with a -60 mV resting potential is innervated by

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HELP ASAP!!

QUESTION 4 A neuron with a -60 mV resting potential is innervated by many synapses where release of GABA opens postsynaptic Cl- channels. Initially, the neuron expresses large numbers of Na+-C cotransporters (symporters) in its membrane. Stimulation of the synaptic inputs causes a small hyperpolarizing postsynaptic potential (PSP) in the neuron. Now, imagine that the neuron decreases the number of functional Na+-Cl- cotransporters. Once the full effects of this change have been achieved, which of the following changes in the PSP would you expect to see? O a. The PSP would become depolarizing. O D. The PSP would remain unchanged. O C. The PSP would still be hyperpolarizing, but larger (more negative) than before. O d. The PSP would disappear, i.e., stimulation of the synaptic inputs would not generate a PSP. e. Insufficient information is given to answer this question.

Explanation / Answer

Answer is C – The PSP would still be hyperpolarizing, but larger (more negative) than before.

GABA is an inhibitory neurotransmitter. The electric potential initially is -60 mV, transmitter release will inhibit the postsynaptic cell. the electrochemical driving force would cause the Cl ions to flow inside the cell and therefore hyperpolarizing inhibitory postsynaptic potential.

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