The figure below shows an agarose gel following amplification and electrophoresi

Question

The figure below shows an agarose gel following amplification and electrophoresis of mouse microsatellite DNA marker D5Mit294, as reported by Zhou and Williams (1997, Neurosci. Abstr. 23:864). The lane on the far left is DNA marker, the next two lanes represent DNA from the two parents, the fourth lane is one of their F1 progeny and the remaining lanes are from F2 progeny obtained from F1 sibling matings.

Which term best describes the pattern of inheritance of this microsatellite marker?

A. Dominant B. Recessive C. Incomplete Dominant D. Codominant E. Overdominant

Explanation / Answer

F1-Aa

F2-

Aa-11

AA-2

aa-7

Hence dominant

When a trait is dominant, only one allele is required for the trait to be observed. A dominant allele will mask a recessive allele, if present. A dominant allele is denoted by a capital letter (A versus a). Since each parent provides one allele, the possible combinations are: AA, Aa, and aa. Offspring whose genotype is either AA or Aa will have the dominant trait expressed phenotypically, while aa individuals express the recessive trait.

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