QUESTION 5 1 pointsSave Answer In the thick ascending limb of the loop of Henle

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QUESTION 5 1 pointsSave Answer In the thick ascending limb of the loop of Henle NaCl reabsorption is achieved as shown in the figure. Na+ and CI are taken up from the lumen by the Na /2CI cotransporter which is driven by the Na+ and CI gradients. The Na+ concentration in the epithelial cells is kept low by the Na /K+ ATPase. The CI concentration is kept low by a CI channel in the basolateral membrane which is driven by the membrane potential. K channels are located in the apical and basal membranes and reduce the K gradient across the membranes so it does not interfere with the proper function of the cotransporter. The K channel can also cause the transepithelial potential to be positive on the lumen side. The loop diuretic furosemide (Lasix) blocks the NatK+/2CI cotransporter What effect will furosemide have on NaCI LUMEN INTERSTITIUM Na Nat Na* 2CI ATP Nat CI No effect.

Explanation / Answer

5. Furosemide act by inhibiting the luminal Na-K-Cl cotransporter in the thick ascending limb of loop of henle, thus causing sodium, potacium and chlorine loss in urine. Thus the furosemide block NaCl reabsorption.

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