You work for a pharmaceutical company where you are assigned the task of creatin

Question

You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs). Peroxidine: A drug that inhibits thyroid peroxidase from functioning Cimigine: A drug that inhibits potassium/iodine cotransporter Iodimine: A drug that inhibits iodinase from functioning Aldosine: A drug that inhibits production of angiotensinogen from the liver Aldoramine: A drug that inhibits sodium/iodine cotransporter Thyromine: A drug that stimulates thyroglobulin production Identify the drug(s) that would be successful in treating hyperthyroidism and hypothyroidism, and explain why and how they would be successful.

Explanation / Answer

Hyperthyroidism is condition where we need to control the excessive synthesis of hormone,its production and release so that situation can be controlled.

Since,drugs peroxidine,cimigine,iodimine,aldoramine and aldosine fulfills this situation by their modes of action on steps if synthesis, and release.

In case of hypothyroidism we need more hormone production in active,inactive or storage form so that more can be made available for the situation.

Drug thyromine fits this situation,it stimulates thyroglubulin production which further stimulates production of thyroid hormones.

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