Complete the following sentences: a. Smooth muscle contraction is regulated by c

Question

Complete the following sentences:

a. Smooth muscle contraction is regulated by cytosolic calcium. Following membrane depolarization, the concentration of free calcium ions in the cytosol increases. This calcium binds to ______ to activate smooth muscle myosin based contraction.?

b. The Latch state most likely reflects the force and phosphorylation dependent accumulation of _________ biochemical species in the actomyosin ATPase cycle.

c. When smooth muscle myosin is dephosphorylated, ______ occurs.

d. The proposed hypothesis for how genetic mutations cause HCM (hypertrophic cardiomyopathy) and DCM (Dilated cardiomyopathy) is that _____

Explanation / Answer

Answer a. smooth muscle contraction is regulated by cytosolic calcium. Following membrane depolarization, the concentration of free calcium ions in the cytosol increases. This calcium binds to calmodulin to activate smooth muscle myosin based contraction.

Answer b . The latch state most likely reflects the force and phosphorylation dependent accumulation of cyclic AMP biochemical species in the actomyosin ATPase cycle.

Answer c. When smooth muscle myosin is dephosphorylated, relaxation occurs.

Answer d. The proposed hypothesis for how genetic mutation causes HCM ( hypertrophic cardiomyopathy) and DCM ( dilated cardiomyopathy) is that 4th stage model.

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