The insecticide rotenone inhibits the flow of electrons in the electron transpor
ID: 3523435 • Letter: T
Question
The insecticide rotenone inhibits the flow of electrons in the electron transport system in mitochondria. What is the most likely result?A) The rate of the Krebs cycle reactions will increase. B) ATP production will stop. C) The cells will utilize oxygen more rapidly. D) The transport of pyruvate into the mitochondria will increase. The insecticide rotenone inhibits the flow of electrons in the electron transport system in mitochondria. What is the most likely result?
A) The rate of the Krebs cycle reactions will increase. B) ATP production will stop. C) The cells will utilize oxygen more rapidly. D) The transport of pyruvate into the mitochondria will increase. The insecticide rotenone inhibits the flow of electrons in the electron transport system in mitochondria. What is the most likely result?
A) The rate of the Krebs cycle reactions will increase. B) ATP production will stop. C) The cells will utilize oxygen more rapidly. D) The transport of pyruvate into the mitochondria will increase. A) The rate of the Krebs cycle reactions will increase. B) ATP production will stop. C) The cells will utilize oxygen more rapidly. D) The transport of pyruvate into the mitochondria will increase.
Explanation / Answer
Rotenone works by interfering with the electron transport chain in mitochondria. It inhibits the transfer of electrons from iron-sulfur centers in complex I to ubiquinone. This interferes with NADH during the creation of usable cellular energy (ATP).
The electron transfer through the respiratory chain releases more than enough free energy to form ATP. Thus it is evident that The insecticide rotenone when inhibits the flow of electrons in the electron transport system in mitochondria it severely affects the production of ATP.
Where as the Krebs cycle (called after Hans Krebs) is a part of cellular respiration. Its other names are the citric acid cycle, and the tricarboxylic acid cycle (TCA cycle). It is the series of chemical reactions used by all aerobic organisms to generate energy The Krebs cycle comes after the link reaction and provides the hydrogen and electrons needed for the electron transport chain
It is also evident that the Krebs cycle, is involved in cell respiration and produces NADH and FADH2 for the electron transport chain. The Krebs cycle also produces two ATP, but much more ATP is produced later, in the electron transport chain, so that is not its main purpose.
Coming to the next option :The transport of pyruvate into the mitochondria .:- In aerobic conditions, pyruvate is primarily transported into the mitochondrial matrix and converted to acetyl-coenzyme (acetyl-CoA) and carbon dioxide by the pyruvate dehydrogenase complex (PDC). The transport of pyruvate into the mitochondria is via the transport protein pyruvate translocase. Pyruvate translocase transports pyruvate in a symport fashion with a proton, and hence is active, consuming energy.
As Rotenone inhibits the transfer of electrons from Fe-S centers in complex I to ubiquinone in the electron transport chain. This prevents NADH from being converted into usable cellular energy, i.e. ATP. In mammals and fish, rotenone inhibits the oxidation of NADH to NAD, thereby blocking the oxidation of NAD and the substrates such as glutamate, ?-ketoglutarate, and pyruvate. Rotenone causes inhibition of mitochondrial respiratory chain complex I, which can cause oxidative stress and lead to selective degeneration of striatal-nigral dopamine neurons. Besides complex I inhibition, nitrosative stress, increased nitric oxide and malondialdehyde levels, aggregation of ?-synuclein and polyubiquitin, activation of astrocytes and microglial cells, inflammatory reaction, glutamate excitotoxicity, and neuronal apoptosis are involved in the mechanisms of rotenone-evoked parkinsonism so we cannot say that cells utilize more oxygen rapidly.
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