Cell signaling allows cells to communicate with each other through signal transd

Question

Cell signaling allows cells to communicate with each other through signal transduction pathways. When a paper cut damages skin cells in a finger, the cells near the cut must begin producing new cells to replace the cells that were lost. Growth factor signal molecules are released into the extracellular spaces near the cut. How do adjacent cells respond to these signal molecules?

Put the three phases in the signal transduction pathway in order.

*Growth factor signal molecules cause changes in protein receptors, triggering changes in other proteins in the cell's cytosol.

*Proteins in the cell's cytosol activate proteins in the nucleus, causing the cell to begin the process of mitosis in response

* protein receptors on cells near the cut bind to growth factors signal molecules

Explanation / Answer

protein receptors on cells near the cut bind to growth factors signal molecules (EGF), Growth factor signal molecules cause changes in protein receptors, triggering changes in other proteins in the cell's cytosol (cytoskeleton ). Proteins in the cell's cytosol activate proteins in the nucleus (master control), causing the cell to begin the process of mitosis in response these signals forming new cells to replace old lost ones.

EGFR (epidermal growth factor) modulates HGF (hepatocyte growth factor) /c-Met activity by inducing c-Met ectodomain shedding, and HGF/c-Met transactivates EGFR, leading to an enhanced activation of downstream signaling pathways. Cross talk between EGFR and c-Met may play a key role in regulating wound healing where cell migration, proliferation, and wound healing follow in a sequence.

New blood vessels arise during embryogenesis by two processes: vasculogenesis and angiogenesis.The role of growth factors (GF) in both processes are well established. For example, vascular endothelial growth factor (VEGF)and its receptorsand basic fibroblast growth factor (bFGF)promote not only the initial development of the embryonic vascular network but also the formation of new blood vessels from pre-existing vessels during development, wound healing.

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