You have found that Natasha Romanoff (Black Widow) has cells that are normal for

Question

You have found that Natasha Romanoff (Black Widow) has cells that are normal for secretion of hormones such as prolactin. Because you've mastered the entire secretory pathway of eukaryotic cells, you know what the consequences of specific mutations would be. You produce several double mutants and have Nick Fury track the localization of prolactin Each mutation results in the complete lack of the specific component lines are shown below. + indicates normal component and indicates components .mutation All unlisted components normal in all of the cell lines Note: For the following questions address only the direct effects on prolactin secretion. Other effects of the mutations would definitely happen in the cell but the questions get very complicated when considering all of these I'm not saying that you couldn't deal with all these just that you don't need to. Name ALL the locations (organelles, vesicles, etc.) in order where prolactin will be found in mutant cell line 1. Reminder: all proteins start in the cytosol. Describe any differences (size, modifications, etc) in this prolactin as compared to the normally secreted prolactin. No explanation required.

Explanation / Answer

As in the 1st mutant both dynamins and exportins are absent in the cell. Exportins are useful in exporting RNA molecules from the nuclues in to the cytosol. As exportin is absent in the double mutants, mRNA from nucleus after transcription will not be released in to the cytosol.

Dynamins play role in endocytosis and budding of vesicles from one apparatus and fusing it to another apparatus. That means, once protein is synthesised in the cytosol i.e, in the golgi, it stays inside the golgi as dynamin is absent.

In this case, transcription is happening but translation is not happening. So, no protein is getting synthesized.

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