What is the role of biotin in acetyl-CoA carboxylase? Biotin is a metal cofactor

Question

What is the role of biotin in acetyl-CoA carboxylase? Biotin is a metal cofactor that is coordinated within a heme group in acetyl-CoA carboxylase. It binds to one molecule of bicarbonate to aid in carboxylation of acetyl-CoA. It transfers a growing fatty acid chain from one domain to another in the fatty acid synthase. Biotin is a regulatory protein that assembles the different domains of the fatty acid synthase. Biotin reduces NADP+ to NADPH for use by the ketoreductase (KR) and enoyl reductase (ER) domains of the fatty acid synthase complex.

Explanation / Answer

Option 2 is correct.

Biotin binds to a bicarbonate ion and in the next step it adds the carboxyl group to acetyl coA

This reaction takes place in two sites, in site 1 the attachment takes place while the detachment occurs at the second active site.

This translocation of biotin group is possible due to the flexible linkage between biotin and lysine side chains.

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