Carbamoyl phosphate synthesis is a hugely important reaction in biochemistry --

Question

Carbamoyl phosphate synthesis is a hugely important reaction in biochemistry -- for organisms that use the urea cycle to get rid of nitrogen (including humans, of course).

Which of the following is true about carbamoyl phosphate synthesis?

A. This synthesis provides an immediate (but temporary) solution to the problem that free ammonia (liberated in oxidative deamination) is highly toxic.

B. 2 ATP are consumed in synthesis of carbamoyl phosphate, thus driving the reaction in the direction of products.

C. CO2 (in the form of bicarbonate) is one of the compounds from which carbamoyl phosphate is synthesized.

D. The phosphate in carbamoyl phosphate comes from an ATP molecule.

E. All of the above are true.

Explanation / Answer

E. All of the above are true related to carbamoyl phosphate.

Carbamoyl phosphate is synthesised from bicarbonate (which comes from CO2), ammonia (which comes from glutamine) and phosphate (which comes from ATP); using the enzyme carbamoyl phosphate synthetase. 2ATP are consumed in the process.

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