Describe the probable effect in hepatocytes (liver cells) of insulin-stimulated

Question

Describe the probable effect in hepatocytes (liver cells) of insulin-stimulated uptake of glucose into these cells.

Increased glucose levels in the____ stimulate glycolysis, which provides______ for oxidation in the_______ .

The resultant acetyl-CoA can return to the______ (as)_______ and generate precursors for increased fatty acid synthesis. The increased intracellular glucose also stimulates glycogen synthesis.

Here are the words to fill in the blanks:

mitochondrion

pyruvate

citrate

malate

cytosol

oxaloacetate

Explanation / Answer

Increased glucose levels in the Cytosol stimulate glycolysis, which provides pyruvate for oxidation in the mitochondrion.

The resultant acetyl-CoA can return to the oxaloacetate (as) Citrate and generate precursors for increased fatty acid synthesis. The increased intracellular glucose also stimulates glycogen synthesis.

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