20. Which of the following increases the affinity of hemoglobin for oxygen? A. a

Question

20. Which of the following increases the affinity of hemoglobin for oxygen? A. an increase in BPG concentration. B. the formation of N-terminal carbamates. C. raising pH. D. Oxygen binding E. More than one of the above increase affinity 21 When oxygen binds to a heme-containing protein, the two open coordination bonds of Fe are occupied by A) one O atom and one amino acid atom. B) one O2 molecule and one amino acid atom. C) one O2 molecule and one heme atom. D) two O atoms. E) two O2 molecules 22. Which of the following is not correct concerning 2,3-bisphosphoglycerate (BPG)? A) It binds at a distance from the heme groups of hemoglobin B) It binds with lower affinity to fetal hemoglobin than to adult hemoglobin. C) It increases the affinity of hemoglobin for oxygen. D) It is an allosteric modulator. E) It is normally found associated with the hemoglobin extracted from red blood cells. An allosteric interaction between a ligand and a protein is one in which: A) binding of a molecule to a binding site affects binding of additional molecules to the same site. properties of another site on the protein. D multiple molecules of the same ligand can bind to the same binding site. E) two or more different ligands can bind to the same binding site.

Explanation / Answer

Ans 20. E . More than one of above increase affinity

The Affinity of hemoglobin for oxygen increases as the pH increases because a low or acidic pH stimulates the oxygen unloading from hemoglobin to the tissues. Increase in pCO2 levels also inhibit the hemoglobin affinity so oxygen binding increases the affinity.

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