QUESTION # 2 Describe the lifecycle of Plasmodium , the parasite that causes mal

Question

    QUESTION # 2 Describe the lifecycle of Plasmodium, the parasite that causes malaria.Start with infection. Describe the role of the sporozoites,merozoites, and gamteocytes in the life cycle, and specify whereyou will find each of these forms of the parasite. Specify whichprocesses occur in the human host and which occur in theAnopholes mosquito host. Include information on bothsexual and asexual reproduction of the parasite. Explain howPlasmodium is able to evade the human immune system, andwhat stages of the life cycle are associated with disease symptoms.If you were a research scientist studying malaria, which of thelife stages of Plasmodium, or its mosquito insect vector,would you target for disease control, and why?     QUESTION # 2 Describe the lifecycle of Plasmodium, the parasite that causes malaria.Start with infection. Describe the role of the sporozoites,merozoites, and gamteocytes in the life cycle, and specify whereyou will find each of these forms of the parasite. Specify whichprocesses occur in the human host and which occur in theAnopholes mosquito host. Include information on bothsexual and asexual reproduction of the parasite. Explain howPlasmodium is able to evade the human immune system, andwhat stages of the life cycle are associated with disease symptoms.If you were a research scientist studying malaria, which of thelife stages of Plasmodium, or its mosquito insect vector,would you target for disease control, and why?

Explanation / Answer

Life cycle ofplasmodium : Sporozoites enter the blood stream When aninfected mosquito takes a blood meal from a person. The Sporozoitemigrates to the liver , where they multiply , transforming liverhepatocytes into gaint multinucleate schizonts, which releasethousands of merozoites into the blood stream.The Merozoites infectred blood cells, which eventually rupture , releasing moremerozoites. Eventually some of the merozoites differentiate intomale and female gametocytes which are injested by a mosquito anddifferentiate into gametes. The gametes fuse to form azygote thatdifferentiates tothe sporozoite stagewithinth      e salivary gland of themosquito

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