Electrophoresis Case Study Help: A 32-year-old woman developed progressive fatig

Question

Electrophoresis Case Study Help:

A 32-year-old woman developed progressive fatigue and, later, edema in her ankles and in other dependent regions of her body when she lay down for prolonged periods. Dipstick urinalysis revealed 4-plus protein. Her serum albumin was below the reference range and her serum cholesterol was significantly elevated. Renal biopsy showed extensive glomerular involvement.

1.         What is significant in the findings?

            The high protein, cholesterol, and renal biopsy findings are all significant.

2.         What is her diagnosis?

             Her diagnosis is

3.         Why are the proteins in the alpha-2 and beta regions increased?

4.         Why is the patient edematous?

Explanation / Answer

1. The high protein, cholesterol, and renal biopsy findings all are significant as in these conditions it might cause inadequate pumping of the blood from her veins (venous insufficiency). There is also increase in back-pressure in her veins which forces fluid stay in the extremities (especially in the ankles and feet) and the excess fluid then leaks into the interstitial tissue spaces, causing edema.

2. Her diagnosis is edema..i.e excessive intake of salt.

3. The proteins in the alpha-2 raise because 10-fold increase or greater in association with glomerular protein loss, as in nephrotic syndrome and beta regions Increased due to the increased level of free transferrin is typical of iron deficiency anemia.

4. The patient with edematous is have following problems i.e.

- increased permeability of the capillary walls;

-increased capillary pressure due to venous obstruction or heart failure

-lymphatic obstruction;

-disturbances in renal function;

-reduction of plasmaproteins

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