1- pK a of methamphetamine is around 10. When performing an acid-base extraction

Question

1- pKa of methamphetamine is around 10. When performing an acid-base extraction of methamphetamine using water and hexanes, to what pH should you adjust the aqueous layer so that the methamphetamine is effectively extracted into the hexanes layer?
2- Name an organic solvent that is generally suitable for separating the free base from the salt form of an organic base (e.g. cocaine) using the “dry solvent” extraction technique. 1- pKa of methamphetamine is around 10. When performing an acid-base extraction of methamphetamine using water and hexanes, to what pH should you adjust the aqueous layer so that the methamphetamine is effectively extracted into the hexanes layer?
2- Name an organic solvent that is generally suitable for separating the free base from the salt form of an organic base (e.g. cocaine) using the “dry solvent” extraction technique.
2- Name an organic solvent that is generally suitable for separating the free base from the salt form of an organic base (e.g. cocaine) using the “dry solvent” extraction technique.

Explanation / Answer

if we require methamphetamine , then we need it ionic state

which is deprotonated

when pH = 10, then there is 50% protonation and 50% deprotonation

therefore

adjust to basic pH

basic pH ensures there will be protonation, i.e. NH2 --> NH3+

therefore, it becomes a cation

will be soluble in aqueous layer

Q2

typically, hexane/octane are used, or any other alkane which is very nonpolar

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