Different steps of the oxidative decarboxylation of pyruvate by the pyruvate deh

Question

Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase (PDH) complex are given below. Place these five steps in the correct order. Note that thiamine pyrophosphate, TPP, is sometimes called thiamine diphosphate, TDP.

FADH2 is reoxidized to FAD reducing NAD* to NADH The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2 The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide

Explanation / Answer

five-step process --

5. Step E: As a side reaction, NAD+ becomes reduced to NADH.

2pyruvate+2NAD++2coA2acetyl coA+2NADH+2CO2

so correct order sequence here is, 3 2 5 4 1

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