Latent gene regulatory proteins are often activated through regulated proteolysi
ID: 57045 • Letter: L
Question
Latent gene regulatory proteins are often activated through regulated proteolysis. Choose the pathways below where latent genes are activated via regulated proteolysis:
Wnt
Stat1/Stat2
Notch
NFKB
The following type of protein acts to turn on/off signaling by removing phosphate groups from tyrosines:
kinase
protease
phosphatase
nuclease
PI3 Kinase can be activated by Ras, GPCRs and RTKs. Select the best function of PI3 kinase from the choices below:
Phosphorylates inositol phospholipids on cell surface receptors creating binding sites for other signaling molecules
Phosphorylates receptor cytoplasmic tails allowing for recruitment of MAP kinases resulting in gene expression
Phosphorylates receptor cytoplasmic tails allowing for recruitment of Ras, resulting in activation of multiple signaling pathways
Phosphorylates inositol phospholipids on the plasma membrane to create binding sites for other signaling molecules
Wnt
B.Stat1/Stat2
C.Notch
D.NFKB
The following type of protein acts to turn on/off signaling by removing phosphate groups from tyrosines:
A.kinase
B.protease
C.phosphatase
D.nuclease
PI3 Kinase can be activated by Ras, GPCRs and RTKs. Select the best function of PI3 kinase from the choices below:
Phosphorylates inositol phospholipids on cell surface receptors creating binding sites for other signaling molecules
B.Phosphorylates receptor cytoplasmic tails allowing for recruitment of MAP kinases resulting in gene expression
C.Phosphorylates receptor cytoplasmic tails allowing for recruitment of Ras, resulting in activation of multiple signaling pathways
D.Phosphorylates inositol phospholipids on the plasma membrane to create binding sites for other signaling molecules
Explanation / Answer
1. (D) NFKB is regulated by proteolysis of negative regulatory kB
2. (A) Kinase is a type of protein acts to turn on/off signaling by removing phosphate groups from tyrosines
3. (D) Phosphorylates inositol phospholipids on the plasma membrane to create binding sites for other signaling molecules
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