In the original development of iPSCs, pluripotency was induced by the addition o

Question

In the original development of iPSCs, pluripotency was induced by the addition of four transcription factors (Oct4, Sox2, cMyc and Klf4). These proteins are encoded in the human genome, but are not active in differentiated cells. Transcription factors like these illuminate one of the problems with the ”one gene: one enzyme” hypothesis. How do transcription factors show that “one gene: one enzyme” is insufficient?

A. Transcription factors are not coded by genes.

B. Transcription factors are coded by genes, but are not enzymes.

C. Multiple transcription factors can be coded by the same gene.

D. Multiple genes can code for the same transcription factor.

A. Transcription factors are not coded by genes.

B. Transcription factors are coded by genes, but are not enzymes.

C. Multiple transcription factors can be coded by the same gene.

D. Multiple genes can code for the same transcription factor.

Explanation / Answer

C. Multiple transcription factors can be coded by the same gene.

Transcription factors are the proteins coded by genome, which bind to specific DNA sites to control rate of gene transcription. Alternate splicing allows the same gene to code for more than two transcription factors (proteins).

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